Common molecular basis of aging and cancer dynamics: complex interactions among age, diseases, external stressors, and environmental factors

Sharma, Nilesh Kumar*

Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India

*Correspondence to: Nilesh Kumar Sharma, MD, nilesh.sharma@dpu.edu.in.

Abstract

There are incremental efforts to understand the multifaceted aspects of aging, particularly focusing on its biological interplay with various environmental stressors and diseases such as cancer. The concept of biological age, which is distinct from chronological age, and its importance in predicting disease onset and mortality patterns are emphasized. Furthermore, exploration of the reversible nature of biological aging under different stress conditions, such as surgery, pregnancy, and diseases such as cancer and coronavirus disease 2019, is intriguing. This narrative review attempts to address the potential impact of viral infections such as severe acute respiratory syndrome coronavirus 2 and the altered landscape of diseases such as cancer on biological aging and their interconnected relationships. Additionally, it also touches upon the influence of emerging technologies, particularly artificial intelligence-driven machines, on aging dynamics, prompting further research in this area. This article may provide insight into a comprehensive framework for interdisciplinary research to better understand the complex interactions among age-related dynamics, diseases, external stressors, and environmental factors, with implications for future interventions and healthcare strategies.

衰老和癌症动态的共同分子基础：年龄、疾病、外部压力与环境因素之间复杂的互作

摘要

人们正逐步努力了解衰老的多方面问题，尤其侧重于衰老与各种环境压力和癌症等疾病之间的生物相互作用，及生物年龄有别于实龄的概念，在预测疾病发病和死亡模式方面非常重要。此外，在不同的压力条件下，如手术、妊娠以及癌症和COVID-19 等疾病，生物衰老的可逆性探索始终引人关注。这篇叙述性综述试图探讨 SARS-CoV-2 等病毒感染和癌症等疾病的改变对生物衰老的潜在影响以及相互关联的关系。此外，文章还谈到了新兴技术，特别是人工智能驱动的机器对衰老动态的影响，从而促使人们在这一领域开展进一步的研究。文章可为跨学科研究提供一个全面的框架，以更好地理解与年龄相关的动态、疾病、外部压力因素和环境因素之间复杂的相互作用，并对未来的干预措施和医疗保健策略产生影响。