Comprehensive strategy of sonodynamic therapy and gas therapy on tumor treatment

Zhao, Lilin#; Zhang, Yaqi#; Huang, Qian#; Zhang, Ting*,#

Author Information

Department of Ultrasound, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu Province, China

*Correspondence to: Ting Zhang, PhD, zhangting@jszlyy.com.cn

#These authors contributed equally to the work.

Funding:This work was funded by Scientific Research Program of Jiangsu Commission of Health (No. ZD2021014); and International (Regional) Cooperation and Exchange (ICE) Projects of the National Natural Science Foundation of China (NSFC) (No. 62120106002).

Abstract

Sonodynamic therapy has emerged as a novel non-invasive treatment for cancer with limited single effects. To achieve optimal therapeutic efficacy, sonodynamic therapy frequently needs to be combined with other therapeutic strategies. By exploiting the biological properties of specific gas molecules, gas therapy is an emerging tumor treatment that exerts direct or indirect inhibitory effects on tumor cells. This review systematically examines the rationales, methodologies, and outcomes of sonodynamic therapy and gas therapy combinatorial strategies for malignant tumors. There is a synergistic effect between sonodynamic therapy and gas therapy in tumor treatment. The ultrasound-induced cavitation enhances tissue permeability for improved gas delivery, while gas molecules concurrently sensitize sonodynamic reactions and ameliorate tumor hypoxia. The interaction significantly enhances the therapeutic effect of tumors. Moreover, the combination of sonodynamic therapy with other therapeutic modalities can significantly enhance the anti-tumor efficacy, improve the therapeutic precision and safety, while improve the tumor microenvironment. This combined treatment strategy can also reduce side effects and has a broad clinical application perspective.

摘要

声动力疗法已成为一种新型的癌症非侵入性治疗方法，但其单一效果有限。为达到最佳治疗效果，声动力疗法常需与其他治疗策略联合。气体疗法是利用特定气体分子的生物学特性，对肿瘤细胞产生直接或间接抑制作用的新兴肿瘤治疗方法。本综述系统梳理了声动力疗法与气体疗法联合治疗恶性肿瘤的理论基础、方法策略及研究成果。在肿瘤治疗中，声动力疗法与气体疗法之间存在协同效应：超声诱导的空化作用可增强组织通透性以改善气体递送，而气体分子同时能增敏声动力反应并改善肿瘤乏氧状态。这种相互作用显著增强了肿瘤的治疗效果。此外，声动力疗法与其他治疗方式的联合能够显著增强抗肿瘤疗效，提高治疗的精准性和安全性，同时改善肿瘤微环境。这种联合治疗策略还能减少副作用，具有广阔的临床应用前景。