Perioperative oxygen administration for adults undergoing major noncardiac surgery: a narrative review

Wang, Huixian1,#; Wang, Zhi1,#; Wu, Qi1; Yang, Yuguang1; Liu, Shanshan2; Bian, Jinjun1,*; Bo, Lulong1,*.

¹Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China²Department of Anesthesiology, Chenggong Hospital Affiliated to Xiamen University, Xiamen, Fujian Province, China

Abstract

Perioperative oxygen administration, a topic under continuous research and debate in anesthesiology, strives to optimize tissue oxygenation while minimizing the risks associated with hyperoxia and hypoxia. This review provides a thorough overview of the current evidence on the application of perioperative oxygen in adult patients undergoing major noncardiac surgery. The review begins by describing the physiological reasoning for supplemental oxygen during the perioperative period and its potential benefits while also focusing on potential hyperoxia risks. This review critically appraises the existing literature on perioperative oxygen administration, encompassing recent clinical trials and meta-analyses, to elucidate its effect on postoperative results. Future research should concentrate on illuminating the optimal oxygen administration strategies to improve patient outcomes and fine-tune perioperative care protocols for adults undergoing major noncardiac surgery. By compiling and analyzing available evidence, this review aims to provide clinicians and researchers with comprehensive knowledge on the role of perioperative oxygen administration in major noncardiac surgery, ultimately guiding clinical practice and future research endeavors.

摘要：围手术期给氧是麻醉学中一个不断研究和争论的话题，其致力于优化组织氧合，同时最大限度地降低与高氧和缺氧的风险。此次综述首先概述了围手术期补充氧气的生理原因及其潜在益处，同时也说明了潜在的高氧风险；然后批判性地总结了现有的围手术期给氧的研究，包括最近的临床试验和荟萃分析，以阐明其对预后的影响。未来应集中于阐明最佳的给氧策略，以改善患者的预后，并微调接受重大非心脏手术的成年人的围手术期护理方案。该综述旨在为临床医生和研究人员提供接受大型非心脏手术的成年患者中应用围手术期氧气的证据，最终指导临床实践和未来的研究工作。