Oxygen–ozone therapy for myocardial ischemic stroke and cardiovascular disorders

Pandolfi, Sergio1,2; Chirumbolo, Salvatore3,*; Franzini, Marianno1,2; Tirelli, Umberto4; Valdenassi, Luigi1,2

¹High School Master of Oxygen Ozone Therapy, University of Pavia, Pavia, Italy²Italian Scientific Society of OxygenOzone Therapy (SIOOT), Gorle, Italy³Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy⁴Tirelli Medical Group, Pordenone, Italy

Cardiovascular diseases (CVDs) represent a major concern for human health worldwide. Emergencies in this field include wide repertories of studies dealing primarily with CVD prevention. In addition to dietary habits and lifestyles, medical knowledge is fully needed to improve public educational programs toward cardiovascular risk factors and to enrich the endowment of pharmaceutical options and therapies to address CVDs, particularly for ischemic damage due to an impairment in the endothelial–myocardial relationship. Because ozone is a stimulator of the endothelial nitric oxide synthase/nitric oxide pathway, ozone therapy has been widely demonstrated to have the ability to counteract endothelial-cardiac disorders, providing a novel straightforward opportunity to reduce the impact of CVDs, including atrial fibrillation. In this review, we attempt to establish a state-of-the-art method for the use of ozone in CVD, suggesting that future remarks be addressed to provide fundamental insights into this issue. The purpose of this study was to highlight the role of ozone in the adjunctive medical treatment of cardiovascular pathologies such as acute myocardial infarction due to ischemic disorders.

摘要：心血管疾病是全球性健康问题。除饮食习惯和生活方式外，还完全需要改善针对心血管危险因素的公共教育计划，并丰富治疗心血管疾病的药物选择和疗法，特别是针对内皮-心肌关系受损引起的缺血性损伤。由于臭氧是内皮型一氧化氮合酶/一氧化氮通路的刺激剂，因而臭氧疗法已被广泛证明具有对抗内皮型心脏疾病的能力，这为缓解心血管疾病（包括房颤）提供了一种新的可能。此次综述试图建立一种在心血管疾病中使用臭氧的最先进方法，以关注臭氧在心血管疾病辅助治疗中的作用，如缺血性疾病引起的急性心肌梗死。